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K⁺ channel blockers and Ca²⁺ signals in basket cell terminals

B. Robertson and A. Southan

A key issue in neurophysiology is understanding the mechanisms of fast synaptic transmission between neurones. Progress is being made on many fronts, using powerful techniques to describe such physiological processes in terms of their molecular components. For instance, we are now beginning to define the molecular identity of several key ion channels at synapses between basket cells and Purkinje cells in the cerebellar cortex. The cerebellum has long been a happy and profitable hunting ground for physiologists and anatomists. Indeed, some of the most significant advances in understanding how neurones communicate have come from studies of the cerebellar cortex, and it is still an incredibly useful in vitro preparation today, as the article by Tan & Llano (1999) in this issue of The Journal of Physiology shows.

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