HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Grillner, S. Articles by El Manira, A. Search for Related Content PubMed PubMed Citation Articles by Grillner, S. Articles by El Manira, A. Related Collections Review articles

Ion channels of importance for the locomotor pattern generation in the lamprey brainstem-spinal cord

Sten Grillner, Peter Wallén, Russell Hill, Lorenzo Cangiano and Abdeljabbar El Manira

The intrinsic function of the spinal network that generates locomotion can be studied in the isolated brainstem-spinal cord of the lamprey, a lower vertebrate. The motor pattern underlying locomotion can be elicited in the isolated spinal cord. The network consists of excitatory glutamatergic and inhibitory glycinergic interneurones with known connectivity. The current review addresses the different subtypes of ion channels that are present in the cell types that constitute the network. In particular the roles of the different subtypes of Ca²⁺ channels and potassium channels that regulate integrated neuronal functions, like frequency regulation, spike frequency adaptation and properties that are important for generating features of the motor pattern (e.g. burst termination), are reviewed. By knowing the role of an ion channel at the cellular level, we also, based on previous knowledge of network connectivity, can understand which effect a given ion channel may exert at the different levels from molecule and cell to network and behaviour.

This article has been cited by other articles:

				I. Hurwitz, A. Ophir, A. Korngreen, J. Koester, and A. J. Susswein Currents Contributing to Decision Making in Neurons B31/B32 of Aplysia J Neurophysiol, February 1, 2008; 99(2): 814 - 830. [Abstract] [Full Text] [PDF]

				P. Wallen, B. Robertson, L. Cangiano, P. Low, A. Bhattacharjee, L. K. Kaczmarek, and S. Grillner Sodium-dependent potassium channels of a Slack-like subtype contribute to the slow afterhyperpolarization in lamprey spinal neurons J. Physiol., November 15, 2007; 585(1): 75 - 90. [Abstract] [Full Text] [PDF]

				S. Tazerart, J.-C. Viemari, P. Darbon, L. Vinay, and F. Brocard Contribution of Persistent Sodium Current to Locomotor Pattern Generation in Neonatal Rats J Neurophysiol, August 1, 2007; 98(2): 613 - 628. [Abstract] [Full Text] [PDF]

				M. Huss, A. Lansner, P. Wallen, A. El Manira, S. Grillner, and J. H. Kotaleski Roles of Ionic Currents in Lamprey CPG Neurons: A Modeling Study J Neurophysiol, April 1, 2007; 97(4): 2696 - 2711. [Abstract] [Full Text] [PDF]

				I. A. Rybak, N. A. Shevtsova, M. Lafreniere-Roula, and D. A. McCrea Modelling spinal circuitry involved in locomotor pattern generation: insights from deletions during fictive locomotion J. Physiol., December 1, 2006; 577(2): 617 - 639. [Abstract] [Full Text] [PDF]

				K. C. Cowley, E. Zaporozhets, J. N. MacLean, and B. J. Schmidt Is NMDA Receptor Activation Essential for the Production of Locomotor-Like Activity in the Neonatal Rat Spinal Cord? J Neurophysiol, December 1, 2005; 94(6): 3805 - 3814. [Abstract] [Full Text] [PDF]

				E. J. Schwartz, T. Gerachshenko, and S. Alford 5-HT Prolongs Ventral Root Bursting Via Presynaptic Inhibition of Synaptic Activity During Fictive Locomotion in Lamprey J Neurophysiol, February 1, 2005; 93(2): 980 - 988. [Abstract] [Full Text] [PDF]

				L. Cangiano and S. Grillner Mechanisms of Rhythm Generation in a Spinal Locomotor Network Deprived of Crossed Connections: The Lamprey Hemicord J. Neurosci., January 26, 2005; 25(4): 923 - 935. [Abstract] [Full Text] [PDF]

				G. Viana Di Prisco and S. Alford Quantitative Investigation of Calcium Signals for Locomotor Pattern Generation in the Lamprey Spinal Cord J Neurophysiol, September 1, 2004; 92(3): 1796 - 1806. [Abstract] [Full Text] [PDF]

				D. Le Ray, F. Brocard, and R. Dubuc Muscarinic Modulation of the Trigemino-Reticular Pathway in Lampreys J Neurophysiol, August 1, 2004; 92(2): 926 - 938. [Abstract] [Full Text] [PDF]

				M. D. Womack and K. Khodakhah Dendritic Control of Spontaneous Bursting in Cerebellar Purkinje Cells J. Neurosci., April 7, 2004; 24(14): 3511 - 3521. [Abstract] [Full Text] [PDF]

				S. Alford, E. Schwartz, and G. V. Di Prisco The Pharmacology of Vertebrate Spinal Central Pattern Generators Neuroscientist, June 1, 2003; 9(3): 217 - 228. [Abstract] [PDF]

				R. R. Buss, C. W. Bourque, and P. Drapeau Membrane Properties Related to the Firing Behavior of Zebrafish Motoneurons J Neurophysiol, February 1, 2003; 89(2): 657 - 664. [Abstract] [Full Text] [PDF]

				M. M. Martin Changes in Electrophysiological Properties of Lamprey Spinal Motoneurons During Fictive Swimming J Neurophysiol, November 1, 2002; 88(5): 2463 - 2476. [Abstract] [Full Text] [PDF]

				L. Cangiano, P. Wallen, and S. Grillner Role of Apamin-Sensitive KCa Channels for Reticulospinal Synaptic Transmission to Motoneuron and for the Afterhyperpolarization J Neurophysiol, July 1, 2002; 88(1): 289 - 299. [Abstract] [Full Text] [PDF]

				M. M. Shah and D. G. Haylett K+ Currents Generated by NMDA Receptor Activation in Rat Hippocampal Pyramidal Neurons J Neurophysiol, June 1, 2002; 87(6): 2983 - 2989. [Abstract] [Full Text] [PDF]