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This Article Full Text Full Text (PDF) All Versions of this Article: 554/1/236    most recent jphysiol.2003.054726v1 Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Wang, L. Articles by Jacob, T. Search for Related Content PubMed PubMed Citation Articles by Wang, L. Articles by Jacob, T.

School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3US, UK

Of those people who are anosmic to androstenone, a proportion can acquire sensitivity to it by repeated exposure and even those who are able to smell it can lower their threshold with this treatment. Using olfactory threshold testing, intranasal electrophysiology and EEG we show for the first time that: (1) the subjects' detection threshold is proportional to the amplitude of the olfactory evoked potential (EOG) recorded inside the nose; (2) the EOG amplitude is correlated with the amplitude of the olfactory event-related potential (OERP) recorded on the scalp; and (3) with repetitive exposure, human subjects acquire a reduced threshold for androstenone and, as they do so, their EOG and OERP increase. These observations support the existence of odourant-specific plasticity in the peripheral olfactory system.

(Received 8 September 2003; accepted after revision 27 October 2003; first published online 7 November 2003)
Corresponding author T. Jacob: School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3US, UK.  Email: jacob{at}cardiff.ac.uk

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