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J Physiol Volume 554, Number 1, 56-63, January 1, 2004 DOI: 10.1113/jphysiol.2003.049361
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TOPICAL REVIEW

Functional genomics in rodent models of hypertension

Martin W. McBride, Fadi J. Charchar, Delyth Graham, William H. Miller, Pamela Strahorn, Fiona J. Carr and Anna F. Dominiczak

BHF Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, University of Glasgow, Western Infirmary, Glasgow G11 6NT, UK

Inbred strains of rodents have been used to study mammalian physiology and pathophysiology in an attempt to understand the contribution of genes in the pathogenesis of the disease process. In this review we focus on experimental animal models to identify quantitative trait loci (QTL) and possible strategies for identifying underlying genetic determinants responsible for hypertension. Confirmation of the existence of the QTL and dissection of the implicated region can be undertaken by production of either recombinant inbred, consomic or congenic strains. Despite complex interactions and the relatively few confirmed causative genes underlying QTL, recent developments in rat genome resources and advancement in statistical and bioinformatic methods will facilitate the identification of major gene(s) responsible for complex, polygenic traits.

(Received 30 June 2003; accepted after revision 16 October 2003; first published online 17 October 2003)
Corresponding author A. F. Dominiczak: BHF Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, University of Glasgow, Western Infirmary, Glasgow G11 6NT, UK.  Email: ad7e{at}clinmed.gla.ac.uk




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