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TOPICAL REVIEW |
Department of Biochemistry and Molecular Biophysics and Howard Hughes Medical Institute, Columbia University, 650 West 168th Street, New York, NY 10032, USA
The application of X-ray diffraction has allowed the structure of the ligand-binding core of AMPA receptors to be determined. Here I review the insights that this has given into the molecular mechanisms of activation and desensitization of these receptors.
(Received 9 October 2003;
accepted after revision 24 November 2003;
first published online 28 November 2003)
Corresponding author E. Gouaux: Department of Biochemistry and Molecular Biophysics and Howard Hughes Medical Institute, Columbia University, 650 West 168th Street, New York, NY 10032, USA. Email: jeg52{at}columbia.edu
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