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J Physiol Volume 562, Number 1, 3-8, January 1, 2005 DOI: 10.1113/jphysiol.2004.074641
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Symposium Reports

Persistent gamma oscillations in superficial layers of rat auditory neocortex: experiment and model

Roger D. Traub1, Andrea Bibbig1, Fiona E. N. LeBeau2, Mark O. Cunningham2 and Miles A. Whittington2

1 Departments of Physiology and Pharmacology, and of Neurology, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
2 School of Biomedical Sciences, Worsley Building, University of Leeds, Leeds LS2 9JT, UK

Abstract

Persistent in vitro gamma oscillations, induced by bath application of carbachol and kainate (amongst other drugs), were discovered by Eberhard Buhl and collaborators in 1998. The oscillations are robust, in that they can continue for hours; but the oscillations are also intricate in their mechanisms: they depend upon phasic synaptic excitation and inhibition, upon electrical coupling between interneurones and between pyramidal neurones, and – at least in neocortex – they depend upon complex intrinsic properties of some of the neurones.

(Received 27 August 2004; accepted after revision 8 October 2004; first published online 15 October 2004)
Corresponding author R. D. Traub: Departments of Physiology and Pharmacology, and of Neurology, SUNY Downstate Medical Center, 450 Clarkson Ave., Brooklyn, NY 11203, USA. Email: roger.traub{at}downstate.edu


Footnotes

This report is dedicated to the memory of Eberhard H. Buhl. It was presented at The Journal of Physiology Symposium in honour of the late Eberhard H. Buhl on Structure/Function Correlates in Neurons and Networks, Leeds, UK, 10 September 2004. It was commissioned by the Editorial Board and reflects the views of the authors.




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