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Symposium Reports |
1 Departments of Neurology and Physiology, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Abstract
Plasticity of ligand-gated ion channels plays a critical role in nervous system development, circuit formation and refinement, and pathological processes. Recent advances have mainly focused on the plasticity of channels gated by excitatory amino acids, including their acclaimed role in learning and memory. These receptors, together with voltage-gated ion channels, have also been known to be subjected to a homeostatic form of plasticity that prevents destabilization of the neurone's function and that of the network during various physiological processes. To date, the plasticity of GABAA receptors has been examined mainly from a developmental and a pathological point of view. Little is known about homeostatic mechanisms governing their plasticity. This review summarizes some of the findings on the homeostatic plasticity of tonic and phasic inhibitory activity.
(Received 14 October 2004;
accepted after revision 3 November 2004;
first published online 4 November 2004)
Corresponding author I. Mody: Department of Neurology, RNRC 3-155, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095, USA. Email: mody{at}ucla.edu
This report is dedicated to the memory of Eberhard H. Buhl, a friend and colleague with a vast interest and curiosity about Nature of which inhibition in the brain was only a speck. It was presented at The Journal of Physiology Symposium in honour of the late Eberhard H. Buhl on Structure/Function Correlates in Neurons and Networks, Leeds, UK, 10 September 2004. It was commissioned by the Editorial Board and reflects the views of the authors.
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