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Symposium Reports |
1 University Laboratory of Physiology, Oxford University, Parks Road, Oxford OX1 3PT, UK
2
Centre for the Biology of Memory, Norwegian University of Science and Technology, N-7489 Trondheim, Norway
Abstract
GABAergic interneurones are necessary for the emergence of hippocampal gamma-frequency network oscillations, during which they play a key role in the synchronization of pyramidal cell firing. However, it remains to be resolved how distinct interneurone subtypes contribute to gamma-frequency oscillations, in what way the spatiotemporal pattern of interneuronal input affects principal cell activity, and by which mechanisms the interneurones themselves are synchronized. Here we summarize recent evidence from cholinergically induced gamma-frequency network oscillations in vitro, showing that perisomatic-targeting GABAergic interneurones provide prominent rhythmic inhibition in pyramidal cells, and that these interneurones are synchronized by recurrent excitation. We conclude by presenting a minimal integrate-and-fire network model which demonstrates that this excitatory-inhibitory feedback loop is sufficient to explain the generation of intrahippocampal gamma-frequency oscillations.
(Received 5 November 2004;
accepted after revision 8 November 2004;
first published online 11 November 2004)
Corresponding author O. Paulsen: University Laboratory of Physiology, Oxford University, Parks Road, Oxford OX1 3PT, UK. Email: ole.paulsen{at}physiol.ox.ac.uk
This report was presented at The Journal of Physiology Symposium in honour of the late Eberhard H. Buhl on Structure/Function Correlates in Neurons and Networks, Leeds, UK, 10 September 2004. It was commissioned by the Editorial Board and reflects the views of the authors.
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