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Symposium Reports |
1 Department of Pharmacology, The School of Pharmacy, 2939 Brunswick Square, London WC1N 1AX, UK
Abstract
The cerebral cortex is pivotal in information processing and higher brain function and its laminar structure of six distinct layers, each in receipt of a different constellation of inputs, makes it important to identify connectivity patterns and distinctions between excitatory and inhibitory pathways. The feedforward projections from layer 43 and from 35 target pyramidal cells and to lesser degrees interneurones. Feedback projections from layer 53 and from 34, on the other hand, mainly target interneurones. Understanding the microcircuitry may give some insight into the computation and information processing performed in this brain region.
(Received 6 October 2004;
accepted after revision 9 November 2004;
first published online 11 November 2004)
Corresponding author J. Watts: Department of Pharmacology, School of Pharmacy, 2939 Brunswick Square, London WC1N 1AX, UK. Email: joanne.watts{at}ulsop.ac.uk
This report was presented at The Journal of Physiology Symposium in honour of the late Eberhard H. Buhl on Structure/Function Correlates in Neurons and Networks, Leeds, UK, 10 September 2004. It was commissioned by the Editorial Board and reflects the views of the authors.
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