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This Article Full Text Full Text (PDF) All Versions of this Article: 565/1/197    most recent jphysiol.2004.078139v1 Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Battista, M.-C. Articles by Brochu, M. Search for Related Content PubMed PubMed Citation Articles by Battista, M.-C. Articles by Brochu, M.

Department of
¹ Obstetrics/Gynecology
² Pediatrics
³ Nutrition, Université de Montréal, Montréal, Canada
⁴ Research Center, Hôpital Ste-Justine, Montréal, Québec, Canada
⁵ Centre Hospitalier Universitaire de Québec, Research Center, Université Laval, Québec, Québec, Canada
⁶ Department of Medecine, University of California, San Diego, CA, USA

Epidemiological studies link intra-uterine growth restriction (IUGR) with increased incidence of hypertension and cardiac disease in adulthood. Our rat model of IUGR supports this contention and provides evidence for the programming of susceptibility for hypertension in all offspring. Moreover, in the female offspring only, gross anatomical changes (cardiac ventricle to body ratios) and increased left cardiac ventricular atrial natriuretic peptide (ANP) mRNA levels provide evidence for programming of cardiac disease in this gender. The aim of the current study was to measure changes in cardiac tissue that support remodelling that could be implicated in the initiation of hypertrophy. Adult female rats from our IUGR model and age- and sex-matched controls were killed at 12 weeks of age. Left cardiac ventricles were removed and used for monitoring changes in several key genes, Na⁺,K⁺-ATPase ß1 protein expression, cardiomyocyte morphology and contractility as well as citrate synthase and aconitase activities. When compared to controls, female offspring of our IUGR rat model exhibit higher expression (mRNA) of ANP and the atrial isoform of the myosin light chain, lower levels of Na⁺,K⁺-ATPase ß1 protein, increased cardiomyocyte depth and volume, increased sarcomere length, diminished cardiomyocyte contractility and lower aconitase activity. Female offspring of our IUGR rat model exhibit changes as adults that are consistent with the onset of cardiac remodelling. The decrease in aconitase activity suggests that oxidative stress may be implicated in this response.

(Received 16 February 2005; accepted after revision 14 March 2005; first published online 17 March 2005)
Corresponding author M. Brochu: Centre de recherche, Hôpital Ste-Justine, 3175 Côte Ste-Catherine, Montréal, Québec, Canada H3T 1C5. Email: michele.brochu{at}umontreal.ca

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