| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Symposium reports |
1 Department of Cell and Developmental Biology
2 Graduate program in Cell and Molecular Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
The Na exchanger regulatory factor (NHERF) family of epithelial-enriched PDZ domain scaffolding proteins plays important roles in maintaining and regulating epithelial cell function. The NHERFs exhibit some overlap in tissue distribution and binding partners, suggesting redundant functions. Yet, it is clear that each NHERF protein exhibits distinct properties, translating into unique cellular functions. The work summarized in this review suggests the most recently identified family member, NHERF4, is the most divergent. Additional investigation is needed, however, to understand more completely the role of NHERF4 in the context of the NHERF family.
(Received 21 June 2005;
accepted after revision 28 June 2005;
first published online 1 July 2005)
Corresponding author S. L. Milgram: Department of Cell and Developmental Biology, The University of North Carolina at Chapel Hill, CB 7090, Chapel Hill, NC 27599, USA. Email: milg{at}med.unc.edu
This report was presented at The Journal of Physiology Symposium on PDZ domain scaffolding proteins and their functions in polarized cells, San Diego, CA, USA, 4 April 2005. It was commissioned by the Editorial Board and reflects the views of the authors.
This article has been cited by other articles:
|
|
 |
|
  J. S. Nielsen and K. M. McNagny Novel functions of the CD34 family J. Cell Sci., November 15, 2008; 121(22): 3683 - 3692. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Broere, J. Hillesheim, B. Tuo, H. Jorna, A. B. Houtsmuller, S. Shenolikar, E. J. Weinman, M. Donowitz, U. Seidler, H. R. de Jonge, et al. Cystic Fibrosis Transmembrane Conductance Regulator Activation Is Reduced in the Small Intestine of Na+/H+ Exchanger 3 Regulatory Factor 1 (NHERF-1)- but Not NHERF-2-deficient Mice J. Biol. Chem., December 28, 2007; 282(52): 37575 - 37584. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Li, P. I. Poulikakos, Z. Dai, J. R. Testa, D. J. E. Callaway, and Z. Bu Protein Kinase C Phosphorylation Disrupts Na+/H+ Exchanger Regulatory Factor 1 Autoinhibition and Promotes Cystic Fibrosis Transmembrane Conductance Regulator Macromolecular Assembly J. Biol. Chem., September 14, 2007; 282(37): 27086 - 27099. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Murtazina, O. Kovbasnjuk, N. C. Zachos, X. Li, Y. Chen, A. Hubbard, B. M. Hogema, D. Steplock, U. Seidler, K. M. Hoque, et al. Tissue-specific Regulation of Sodium/Proton Exchanger Isoform 3 Activity in Na+/H+ Exchanger Regulatory Factor 1 (NHERF1) Null Mice: cAMP INHIBITION IS DIFFERENTIALLY DEPENDENT ON NHERF1 AND EXCHANGE PROTEIN DIRECTLY ACTIVATED BY cAMP IN ILEUM VERSUS PROXIMAL TUBULE J. Biol. Chem., August 24, 2007; 282(34): 25141 - 25151. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Donowitz and X. Li Regulatory Binding Partners and Complexes of NHE3 Physiol Rev, July 1, 2007; 87(3): 825 - 872. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Mazzochi, D. J. Benos, and P. R. Smith Interaction of epithelial ion channels with the actin-based cytoskeleton Am J Physiol Renal Physiol, December 1, 2006; 291(6): F1113 - F1122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. H. Hryciw, J. Ekberg, C. Ferguson, A. Lee, D. Wang, R. G. Parton, C. A. Pollock, C. C. Yun, and P. Poronnik Regulation of Albumin Endocytosis by PSD95/Dlg/ZO-1 (PDZ) Scaffolds: INTERACTION OF Na+-H+ EXCHANGE REGULATORY FACTOR-2 WITH ClC-5 J. Biol. Chem., June 9, 2006; 281(23): 16068 - 16077. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Donowitz, S. Milgram, H. Murer, Y. Kurachi, C. Yun, and E. Weinman Coming out of the NHERF family J. Physiol., August 15, 2005; 567(1): 1 - 1. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
