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Symposium reports |
1 Institute of Physiology, Zurich University, CH-8057, Zurich, Switzerland
2 Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA
Regulation of renal proximal tubular reabsorption of phosphate (Pi) is one of the critical steps in Pi homeostasis. Experimental evidence suggests that this regulation is achieved mainly by controlling the apical expression of the Na+-dependent Pi cotransporter type IIa (NaPi-IIa) in proximal tubules. Only recently have we started to obtain information regarding the molecular mechanisms that control the apical expression of NaPi-IIa. The first critical observation was the finding that truncation of only its last three amino acid residues has a strong effect on apical expression. A second major finding was the observation that the last intracellular loop of NaPi-IIa contains sequence information that confers parathyroid hormone (PTH) sensitivity. The use of the above domains of the cotransporter in yeast two-hybrid (Y2H) screening allowed the identification of proteins interacting with NaPi-IIa. Biochemical and morphological, as well as functional, analyses have allowed us to obtain insights into the physiological roles of such interactions, although our present knowledge is still far from complete.
(Received 21 March 2005;
accepted after revision 9 May 2005;
first published online 12 May 2005)
Corresponding author N. Hernando: Physiologisches Institute, Universität Zürich-Irchel, Winterthurerstrasse 190; CH-8057 Zurich, Switzerland. Email: hernando{at}physiol.unizh.ch
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