PERSPECTIVES:

G. D. Lamb

Calpains in muscle: selective and protective?
J Physiol 2007 582: 897. First Published online on June 21, 2007 [Full Text] [PDF]  

L. Bruce Gladden

Is there an intracellular lactate shuttle in skeletal muscle?
J Physiol 2007 582: 899. First Published online on June 28, 2007 [Full Text] [PDF]  

REGULATION OF ION CHANNELS AND TRANSPORTERS BY PIP2:

Brian Robertson

Regulation of ion channels and transporters by phosphatidylinositol 4,5-bisphosphate
J Physiol 2007 582: 901-902. [Full Text] [PDF]  

SYMPOSIUM REPORTS:

Donald W. Hilgemann

On the physiological roles of PIP₂ at cardiac Na⁺–Ca²⁺ exchangers and K_ATP channels: a long journey from membrane biophysics into cell biology
J Physiol 2007 582: 903-909. First Published online on April 26, 2007 [Abstract] [Full Text] [PDF]  

Byung-Chang Suh and Bertil Hille

Regulation of KCNQ channels by manipulation of phosphoinositides
J Physiol 2007 582: 911-916. First Published online on April 5, 2007 [Abstract] [Full Text] [PDF]  

David A. Brown, Simon A. Hughes, Stephen J. Marsh, and Andrew Tinker

Regulation of M(Kv7.2/7.3) channels in neurons by PIP₂ and products of PIP₂ hydrolysis: significance for receptor-mediated inhibition
J Physiol 2007 582: 917-925. First Published online on March 29, 2007 [Abstract] [Full Text] [PDF]  

Tamas Balla

Imaging and manipulating phosphoinositides in living cells
J Physiol 2007 582: 927-937. First Published online on March 29, 2007 [Abstract] [Full Text] [PDF]  

Thomas Voets and Bernd Nilius

Modulation of TRPs by PIPs
J Physiol 2007 582: 939-944. First Published online on March 29, 2007 [Abstract] [Full Text] [PDF]  

Leslie M. Loew

Where does all the PIP₂ come from?
J Physiol 2007 582: 945-951. First Published online on March 29, 2007 [Abstract] [Full Text] [PDF]  

Diomedes E. Logothetis, Dmitry Lupyan, and Avia Rosenhouse-Dantsker

Diverse Kir modulators act in close proximity to residues implicated in phosphoinositide binding
J Physiol 2007 582: 953-965. First Published online on May 10, 2007 [Abstract] [Full Text] [PDF]  

Nikita Gamper and Mark S. Shapiro

Target-specific PIP₂ signalling: how might it work?
J Physiol 2007 582: 967-975. First Published online on April 5, 2007 [Abstract] [Full Text] [PDF]  

RELATED PAPERS:

Joo Hyun Nam, Hoo-Se Lee, Yen Hoang Nguyen, Tong Mook Kang, Sung Won Lee, Hye-Young Kim, Sang Jeong Kim, Yung E. Earm, and Sung Joon Kim

Mechanosensitive activation of K⁺ channel via phospholipase C-induced depletion of phosphatidylinositol 4,5-bisphosphate in B lymphocytes
J Physiol 2007 582: 977-990. First Published online on March 8, 2007 [Abstract] [Full Text] [PDF] Supplemental data  

Alp Yaradanakul, Siyi Feng, Chengcheng Shen, Vincenzo Lariccia, Mei-Jung Lin, Jinsong Yang, Kang T. M., Ping Dong, Helen L. Yin, Joseph P. Albanesi, and Donald W. Hilgemann

Dual control of cardiac Na⁺–Ca²⁺ exchange by PIP₂: electrophysiological analysis of direct and indirect mechanisms
J Physiol 2007 582: 991-1010. First Published online on May 31, 2007 [Abstract] [Full Text] [PDF]  

Chengcheng Shen, Mei-Jung Lin, Alp Yaradanakul, Vincenzo Lariccia, Joseph A. Hill, and Donald W. Hilgemann

Dual control of cardiac Na⁺–Ca²⁺ exchange by PIP₂: analysis of the surface membrane fraction by extracellular cysteine PEGylation
J Physiol 2007 582: 1011-1026. First Published online on May 31, 2007 [Abstract] [Full Text] [PDF]  

Doris K. Nielsen, Annelie Kolbjørn Jensen, Henrik Harbak, Søren C. Christensen, and Lars Ole Simonsen

Cell content of phosphatidylinositol (4,5)bisphosphate in Ehrlich mouse ascites tumour cells in response to cell volume perturbations in anisotonic and in isosmotic media
J Physiol 2007 582: 1027-1036. First Published online on June 7, 2007 [Abstract] [Full Text] [PDF]  

Jong-Woo Sohn, Ajin Lim, Suk-Ho Lee, and Won-Kyung Ho

Decrease in PIP₂–channel interactions is the final common mechanism involved in PKC- and arachidonic acid-mediated inhibitions of GABA_B-activated K⁺ current
J Physiol 2007 582: 1037-1046. First Published online on June 21, 2007 [Abstract] [Full Text] [PDF] Supplemental data  

Erin A. Crowder, Margaret S. Saha, Ryland W. Pace, Honglu Zhang, Glenn D. Prestwich, and Christopher A. Del Negro

Phosphatidylinositol 4,5-bisphosphate regulates inspiratory burst activity in the neonatal mouse preBötzinger complex
J Physiol 2007 582: 1047-1058. First Published online on June 28, 2007 [Abstract] [Full Text] [PDF] Supplemental data  

MOLECULAR AND GENOMIC:

Ya-Chin Yang, Chia-Jen Own, and Chung-Chin Kuo

A hydrophobic element secures S4 voltage sensor in position in resting Shaker K+ channels
J Physiol 2007 582: 1059-1072. First Published online on April 5, 2007 [Abstract] [Full Text] [PDF]  

CELLULAR:

Bret F. Bessac and Andrea Fleig

TRPM7 channel is sensitive to osmotic gradients in human kidney cells
J Physiol 2007 582: 1073-1086. First Published online on May 17, 2007 [Abstract] [Full Text] [PDF]  

Hiroyasu Hatakeyama, Noriko Takahashi, Takuya Kishimoto, Tomomi Nemoto, and Haruo Kasai

Two cAMP-dependent pathways differentially regulate exocytosis of large dense-core and small vesicles in mouse -cells
J Physiol 2007 582: 1087-1098. First Published online on May 17, 2007 [Abstract] [Full Text] [PDF]  

Robert J. Lee, Maria P. Limberis, Michael F. Hennessy, James M. Wilson, and J. Kevin Foskett

Optical imaging of Ca²⁺-evoked fluid secretion by murine nasal submucosal gland serous acinar cells
J Physiol 2007 582: 1099-1124. First Published online on May 24, 2007 [Abstract] [Full Text] [PDF] Supplemental data  

NEUROSCIENCE:

Grégoire Courtine, Susan J. Harkema, Christine J. Dy, Yuri P. Gerasimenko, and Poul Dyhre-Poulsen

Modulation of multisegmental monosynaptic responses in a variety of leg muscles during walking and running in humans
J Physiol 2007 582: 1125-1139. First Published online on April 19, 2007 [Abstract] [Full Text] [PDF]  

Joseph Glykys and Istvan Mody

The main source of ambient GABA responsible for tonic inhibition in the mouse hippocampus
J Physiol 2007 582: 1163-1178. First Published online on May 24, 2007 [Abstract] [Full Text] [PDF]  

Loretta Castelli, Gerardo Biella, Mauro Toselli, and Jacopo Magistretti

Resurgent Na⁺ current in pyramidal neurones of rat perirhinal cortex: axonal location of channels and contribution to depolarizing drive during repetitive firing
J Physiol 2007 582: 1179-1193. First Published online on May 24, 2007 [Abstract] [Full Text] [PDF] Supplemental data  

CARDIOVASCULAR:

Paul Mattick, John Parrington, Efe Odia, Alasdair Simpson, Thomas Collins, and Derek Terrar

Ca²⁺-stimulated adenylyl cyclase isoform AC1 is preferentially expressed in guinea-pig sino-atrial node cells and modulates the I_f pacemaker current
J Physiol 2007 582: 1195-1203. First Published online on May 31, 2007 [Abstract] [Full Text] [PDF]  

Joëlle Abi-Char, Ange Maguy, Alain Coulombe, Elise Balse, Philippe Ratajczak, Jane-Lise Samuel, Stanley Nattel, and Stéphane N. Hatem

Membrane cholesterol modulates Kv1.5 potassium channel distribution and function in rat cardiomyocytes
J Physiol 2007 582: 1205-1217. First Published online on May 24, 2007 [Abstract] [Full Text] [PDF]  

Patrick M. Sonner and Javier E. Stern

Functional role of A-type potassium currents in rat presympathetic PVN neurones
J Physiol 2007 582: 1219-1238. First Published online on May 24, 2007 [Abstract] [Full Text] [PDF]  

RENAL AND ENDOCRINE:

Ekaitz Errasti-Murugarren, Maral Pastor-Anglada, and F. Javier Casado

Role of CNT3 in the transepithelial flux of nucleosides and nucleoside-derived drugs
J Physiol 2007 582: 1249-1260. First Published online on April 5, 2007 [Abstract] [Full Text] [PDF] Supplemental data  

ALIMENTARY:

P. W. M. Janssen, R. G. Lentle, P. Asvarujanon, P. Chambers, K. J. Stafford, and Y. Hemar

Characterization of flow and mixing regimes within the ileum of the brushtail possum using residence time distribution analysis with simultaneous spatio-temporal mapping
J Physiol 2007 582: 1239-1248. First Published online on May 10, 2007 [Abstract] [Full Text] [PDF]  

SKELETAL MUSCLE AND EXERCISE:

P. Gailly, F. De Backer, M. Van Schoor, and J. M. Gillis

In situ measurements of calpain activity in isolated muscle fibres from normal and dystrophin-lacking mdx mice
J Physiol 2007 582: 1261-1275. First Published online on May 17, 2007 [Abstract] [Full Text] [PDF]  

Ida G. Lunde, Merete Ekmark, Zaheer A. Rana, Andres Buonanno, and Kristian Gundersen

PPAR expression is influenced by muscle activity and induces slow muscle properties in adult rat muscles after somatic gene transfer
J Physiol 2007 582: 1277-1287. First Published online on April 26, 2007 [Abstract] [Full Text] [PDF]  

Christian Frøsig, Mini P. Sajan, Stine J. Maarbjerg, Nina Brandt, Carsten Roepstorff, Jørgen F. P. Wojtaszewski, Bente Kiens, Robert V. Farese, and Erik A. Richter

Exercise improves phosphatidylinositol-3,4,5-trisphosphate responsiveness of atypical protein kinase C and interacts with insulin signalling to peptide elongation in human skeletal muscle
J Physiol 2007 582: 1289-1301. First Published online on May 31, 2007 [Abstract] [Full Text] [PDF]  

K. M. Heinemeier, J. L. Olesen, F. Haddad, H. Langberg, M. Kjaer, K. M. Baldwin, and P. Schjerling

Expression of collagen and related growth factors in rat tendon and skeletal muscle in response to specific contraction types
J Physiol 2007 582: 1303-1316. First Published online on May 31, 2007 [Abstract] [Full Text] [PDF]  

INTEGRATIVE:

Yuko Yoshida, Graham P. Holloway, Vladimir Ljubicic, Hideo Hatta, Lawrence L. Spriet, David A. Hood, and Arend Bonen

Negligible direct lactate oxidation in subsarcolemmal and intermyofibrillar mitochondria obtained from red and white rat skeletal muscle
J Physiol 2007 582: 1317-1335. First Published online on June 7, 2007 [Abstract] [Full Text] [PDF]  

Vicky A. Tobin and Mike Ludwig

The role of the actin cytoskeleton in oxytocin and vasopressin release from rat supraoptic nucleus neurons
J Physiol 2007 582: 1337-1348. First Published online on May 3, 2007 [Abstract] [Full Text] [PDF]  

Andrew M. Coney and Janice M. Marshall

Contribution of ₂-adrenoceptors and Y₁ neuropeptide Y receptors to the blunting of sympathetic vasoconstriction induced by systemic hypoxia in the rat
J Physiol 2007 582: 1349-1359. First Published online on May 17, 2007 [Abstract] [Full Text] [PDF]  

Caroline Iglesias, Véronique Marchand-Pauvert, George Loureno, David Burke, and Emmanuel Pierrot-Deseilligny

Task-related changes in propriospinal excitation from hand muscles to human flexor carpi radialis motoneurones
J Physiol 2007 582: 1361-1379. First Published online on May 17, 2007 [Abstract] [Full Text] [PDF]  

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