PERSPECTIVES:

Chris W. Ward and George G. Rodney

Does a lack of RyR3 make mammalian skeletal muscle EC coupling a ‘spark-less’ affair?
J Physiol 2008 586: 313-314. [Full Text] [PDF]  

JOURNAL CLUB:

Brett S. Kirby and Rick E. Carlson

Potassium, contracting myocytes and rapid vasodilatation: peaking more than just our interest?
J Physiol 2008 586: 315-317. First Published online on November 15, 2007 [Full Text] [PDF]  

TOPICAL REVIEWS:

D. H. J. Thijssen, G. A. Rongen, P. Smits, and M. T. E. Hopman

Physical (in)activity and endothelium-derived constricting factors: overlooked adaptations
J Physiol 2008 586: 319-324. First Published online on October 25, 2007 [Abstract] [Full Text] [PDF]  

Janine Reis, Orlando B. Swayne, Yves Vandermeeren, Mickael Camus, Michael A. Dimyan, Michelle Harris-Love, Monica A. Perez, Patrick Ragert, John C. Rothwell, and Leonardo G. Cohen

Contribution of transcranial magnetic stimulation to the understanding of cortical mechanisms involved in motor control
J Physiol 2008 586: 325-351. First Published online on November 1, 2007 [Abstract] [Full Text] [PDF]  

Robert A. Rose and Wayne R. Giles

Natriuretic peptide C receptor signalling in the heart and vasculature
J Physiol 2008 586: 353-366. First Published online on November 15, 2007 [Abstract] [Full Text] [PDF]  

EDITORIAL:

Quentin J. Pittman

Brain adaptations for a successful pregnancy
J Physiol 2008 586: 367. [Full Text] [PDF]  

SYMPOSIUM SECTION REPORTS: BRAIN ADAPTATIONS FOR A SUCCESSFUL PREGNANCY:

Paula J. Brunton and John A. Russell

Attenuated hypothalamo-pituitary-adrenal axis responses to immune challenge during pregnancy: the neurosteroid–opioid connection
J Physiol 2008 586: 369-375. First Published online on November 8, 2007 [Abstract] [Full Text] [PDF]  

David A. Slattery and Inga D. Neumann

No stress please! Mechanisms of stress hyporesponsiveness of the maternal brain
J Physiol 2008 586: 377-385. First Published online on November 1, 2007 [Abstract] [Full Text] [PDF]  

Rachael A. Augustine, Sharon R. Ladyman, and David R. Grattan

From feeding one to feeding many: hormone-induced changes in bodyweight homeostasis during pregnancy
J Physiol 2008 586: 387-397. First Published online on November 22, 2007 [Abstract] [Full Text] [PDF]  

Sarah J. Spencer, Abdeslam Mouihate, Michael A. Galic, and Quentin J. Pittman

Central and peripheral neuroimmune responses: hyporesponsiveness during pregnancy
J Physiol 2008 586: 399-406. First Published online on October 18, 2007 [Abstract] [Full Text] [PDF]  

MOLECULAR AND GENOMIC:

Shin Yuen Nam, Ming Kei Lee, and Kanaga Sabapathy

The tumour-suppressor p53 is not required for pancreatic β cell death during diabetes and upon irradiation
J Physiol 2008 586: 407-417. First Published online on November 15, 2007 [Abstract] [Full Text] [PDF]  

CELLULAR:

Olivier Mignen, Jill L. Thompson, and Trevor J. Shuttleworth

Orai1 subunit stoichiometry of the mammalian CRAC channel pore
J Physiol 2008 586: 419-425. First Published online on November 15, 2007 [Abstract] [Full Text] [PDF] Supplemental Data  

Andreas Beck, Reinhold Penner, and Andrea Fleig

Lipopolysaccharide-induced down-regulation of Ca²⁺ release-activated Ca²⁺ currents (I_CRAC) but not Ca²⁺-activated TRPM4-like currents (I_CAN) in cultured mouse microglial cells
J Physiol 2008 586: 427-439. First Published online on November 8, 2007 [Abstract] [Full Text] [PDF]  

Claude Legrand, Emiliana Giacomello, Christine Berthier, Bruno Allard, Vincenzo Sorrentino, and Vincent Jacquemond

Spontaneous and voltage-activated Ca²⁺ release in adult mouse skeletal muscle fibres expressing the type 3 ryanodine receptor
J Physiol 2008 586: 441-457. First Published online on November 15, 2007 [Abstract] [Full Text] [PDF] Supplemental Data  

Marko Bertog, John E. Cuffe, Sylvain Pradervand, Edith Hummler, Andrea Hartner, Markus Porst, Karl F. Hilgers, Bernard C. Rossier, and Christoph Korbmacher

Aldosterone responsiveness of the epithelial sodium channel (ENaC) in colon is increased in a mouse model for Liddle's syndrome
J Physiol 2008 586: 459-475. First Published online on November 15, 2007 [Abstract] [Full Text] [PDF] Supplemental Data  

NEUROSCIENCE:

M. Derchansky, S. S. Jahromi, M. Mamani, D. S. Shin, A. Sik, and P. L. Carlen

Transition to seizures in the isolated immature mouse hippocampus: a switch from dominant phasic inhibition to dominant phasic excitation
J Physiol 2008 586: 477-494. First Published online on November 8, 2007 [Abstract] [Full Text] [PDF]  

J. Florian, M. Müller-Dahlhaus, Yali Liu, and Ulf Ziemann

Inhibitory circuits and the nature of their interactions in the human motor cortex – a pharmacological TMS study
J Physiol 2008 586: 495-514. First Published online on November 8, 2007 [Abstract] [Full Text] [PDF]  

Kristina S. Vikman, Beth K. Rycroft, and Macdonald J. Christie

Switch to Ca²⁺-permeable AMPA and reduced NR2B NMDA receptor-mediated neurotransmission at dorsal horn nociceptive synapses during inflammatory pain in the rat
J Physiol 2008 586: 515-527. First Published online on November 22, 2007 [Abstract] [Full Text] [PDF]  

Duane C. Button, Jayne M. Kalmar, Kalan Gardiner, Tanguy Marqueste, Hui Zhong, Roland R. Roy, V. Reggie Edgerton, and Phillip F. Gardiner

Does elimination of afferent input modify the changes in rat motoneurone properties that occur following chronic spinal cord transection?
J Physiol 2008 586: 529-544. First Published online on November 15, 2007 [Abstract] [Full Text] [PDF]  

Thomas V. Wuttke, Johann Penzien, Michael Fauler, Guiscard Seebohm, Frank Lehmann-Horn, Holger Lerche, and Karin Jurkat-Rott

Neutralization of a negative charge in the S1–S2 region of the K_V7.2 (KCNQ2) channel affects voltage-dependent activation in neonatal epilepsy
J Physiol 2008 586: 545-555. First Published online on November 15, 2007 [Abstract] [Full Text] [PDF]  

K. Stecina, E. Jankowska, A. Cabaj, L.-G. Pettersson, B. A. Bannatyne, and D. J. Maxwell

Premotor interneurones contributing to actions of feline pyramidal tract neurones on ipsilateral hindlimb motoneurones
J Physiol 2008 586: 557-574. First Published online on November 15, 2007 [Abstract] [Full Text] [PDF]  

Simone Astori and Georg Köhr

Sustained granule cell activity disinhibits juvenile mouse cerebellar stellate cells through presynaptic mechanisms
J Physiol 2008 586: 575-592. First Published online on November 22, 2007 [Abstract] [Full Text] [PDF]  

Andrew Dilley and Geoffrey M. Bove

Disruption of axoplasmic transport induces mechanical sensitivity in intact rat C-fibre nociceptor axons
J Physiol 2008 586: 593-604. First Published online on November 15, 2007 [Abstract] [Full Text] [PDF]  

Salvador Borges, Sarah Lindstrom, Cameron Walters, Ajithkumar Warrier, and Martin Wilson

Discrete influx events refill depleted Ca²⁺ stores in a chick retinal neuron
J Physiol 2008 586: 605-626. First Published online on November 22, 2007 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Kevin J. Sampson, Cecile Terrenoire, Daniel O. Cervantes, Riyaz A. Kaba, Nicholas S. Peters, and Robert S. Kass

Adrenergic regulation of a key cardiac potassium channel can contribute to atrial fibrillation: evidence from an I_Ks transgenic mouse
J Physiol 2008 586: 627-637. First Published online on November 15, 2007 [Abstract] [Full Text] [PDF] Supplemental Data  

RENAL AND ENDOCRINE:

Helen J. Burgess, Victoria L. Revell, and Charmane I. Eastman

A three pulse phase response curve to three milligrams of melatonin in humans
J Physiol 2008 586: 639-647. First Published online on November 15, 2007 [Abstract] [Full Text] [PDF]  

RESPIRATORY:

Takashi Nishino, Shiroh Isono, Norihiro Shinozuka, and Teruhiko Ishikawa

Coughing induced by airway irritation modulates the sensation of air hunger
J Physiol 2008 586: 649-658. First Published online on November 1, 2007 [Abstract] [Full Text] [PDF]  

SKELETAL MUSCLE AND EXERCISE:

José R. Pauli, Eduardo R. Ropelle, Dennys E. Cintra, Marco A. Carvalho-Filho, Juliana C. Moraes, Cláudio T. De Souza, Lício A. Velloso, José B. C. Carvalheira, and Mario J. A. Saad

Acute physical exercise reverses S-nitrosation of the insulin receptor, insulin receptor substrate 1 and protein kinase B/Akt in diet-induced obese Wistar rats
J Physiol 2008 586: 659-671. First Published online on November 1, 2007 [Abstract] [Full Text] [PDF]  

INTEGRATIVE:

Andrea G. Bechtold, Kathy Vernon, Tina Hines, and Deborah A. Scheuer

Genetic predisposition to hypertension sensitizes borderline hypertensive rats to the hypertensive effects of prenatal glucocorticoid exposure
J Physiol 2008 586: 673-684. First Published online on November 15, 2007 [Abstract] [Full Text] [PDF]  

ERRATA:

Errata
J Physiol 2008 586: 685-686. [Full Text] [PDF]  

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